Medical Condition:
Proteins abl, Proto-Oncogene
Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.