Protein lck, Proto-Oncogene

Medical Condition:
Protein lck, Proto-Oncogene

This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation. EC 2.7.11.-.