IGF Type 1 Receptor

Medical Condition:
IGF Type 1 Receptor

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precusor protein. The beta subunit contains an intrisic tyrosine kinase domain. EC 2.7.11.-.