Hypoglycins

Medical Condition:
Hypoglycins

Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the akee plant (Blighia sapida); hypoglycin B is the gamma-glutamyl congener of hypoglycin A; they are very toxic and teratogenic, causing a fall in blood glucose due to the interference of fatty acid and leucine metabolism which leads to vomiting, liver damage, convulsions and death; the syndrome is called Jamaican Vomiting Sickness.