Avian Sarcoma Virus Transforming Protein

Medical Condition:
Avian Sarcoma Virus Transforming Protein

A tyrosine-specific protein kinase encoded by the v-src oncogene of Rous sarcoma virus. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its N-terminal glycine. EC 2.7.11.-.