ATP-Binding Cassette, Sub-Family B, Member 1

Medical Condition:
ATP-Binding Cassette, Sub-Family B, Member 1

A 170 kD transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).